Protein markers tied to chemotherapy success
Doctors in Shanghai have screened two protein markers to determine pancreatic cancer patients' sensitivity to chemotherapy, which may rewrite current treatment guidelines and improve patients' overall survival rate.
The team of researchers from Shanghai Ruijin Hospital said on Monday that the results of the study have been validated in three groups at home and abroad, showing strong clinical applicability.
A paper about the study was published as the cover article in the top international medical journal Nature Medicine on March 19.
More than 330,000 people die from pancreatic cancer worldwide each year, with an overall five-year survival rate of approximately 6 percent, according to the hospital.
By analyzing the data of 191 patients over more than three years of follow-ups, the researchers constructed a prognostic prediction model for pancreatic cancer, and identified two protein markers — NDUFB8 and CEMIP2 — which are able to accurately predict patients' sensitivity to chemotherapy.
Results of the study were independently verified among people with pancreatic cancer in and around Paris, France, and at Fudan University Shanghai Cancer Center and Shanghai Changhai Hospital.
"The research answered one of the two main queries that are current bottlenecks in the field of pancreatic cancer treatment: Which patients are sensitive to chemotherapy and which chemotherapy drugs are they sensitive to?" said Shen Baiyong, a professor at the Pancreatic Disease Diagnosis and Treatment Center of Ruijin Hospital and a leading researcher on the team.
Related articles
GOP secretary of state who spoke out against election denialism wins JFK Profile in Courage Award
Kentucky Republican Secretary of State Michael Adams, who worked to expand early voting in the Blueg2024-05-07The prosecution team in Alec Baldwin's 'Rust' trial has a new attorney
SANTA FE, N.M. (AP) — An attorney has been added to the special prosecution team that is pursuing an2024-05-07Closing prices for crude oil, gold and other commodities
Benchmark U.S. crude oil for May delivery rose 41 cents to $83.14 per barrel Friday. Brent crude for2024-05-07Kings hoping goaltender Cam Talbot can return to early form as Stanley Cup playoffs begin
EL SEGUNDO, Calif. (AP) — It would be an understatement to say that Cam Talbot’s season has been a r2024-05-07Top clubs urge Brazil's soccer federation to suspend league matches because of flooding
SAO PAULO (AP) — Three top-tier clubs on Monday urged Brazil’s soccer federation to suspend their na2024-05-07At playoff time, NHL teams march to the beat of their goaltenders and count on them to save the day
DENVER (AP) — Colorado goaltender Alexandar Georgiev went home after a recent shaky outing and immed2024-05-07
atest comment